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Data from the SUSTAIN and SCALE trials demonstrated that semaglutide therapy is associated with reductions in LDL cholesterol, total cholesterol, and triglycerides, alongside modest increases in HDL.[3,8] For patients already managing cardiovascular risk, this creates a meaningful opportunity: GLP-1-related lipid improvement may reduce or eliminate the need for statin therapy, but that conversation should be guided by lab data — not assumptions
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