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In a single piece, he concisely captures: – the state of the field – the most important clinical trials – where the pipeline is headed These Clinical trials are raising the bar and expanding future treatment options: • Retatrutide → ~24% weight loss (triple agonist) • MariTide → 12–16% weight loss (GLP-1 + GIP antagonist) • CagriSema → up to 20% weight loss + ~2% HbA1c drop • Orforglipron → oral GLP-1, HbA1c –1.5%, weight –7.6% • IcoSema → weekly semaglutide + once-weekly insulin Even more exciting