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However, similar to GLP-1RAs, these agents may induce gastrointestinal adverse effects including anorexia and gastrointestinal discomfort.222 Despite these concerns, such drugs have demonstrated beneficial effects in lowering the incidence of major cardiovascular events and strokes.223 Pharmacokinetically, GLP-1RAs and GLP-1/GIP dual agonists display distinct profiles attributable to their structural heterogeneity, with extended half-lives potentially correlating with an increased risk of adverse events.224 Consequently, vigilant monitoring of patient responses is imperative during treatment, particularly when these agents are administered concomitantly with other medications, to ensure both safety and therapeutic efficacy
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