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GLP-1R expression on intraepithelial lymphocytes and gut macrophages likely mediates these local effects, supporting the therapeutic rationale for GLP-1R-targeted nanotherapies in reducing steroid dependence [400, 401]
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In line with the greater decrease in body weight during semaglutide treatment, we observed a significant difference in bone strength between semaglutide and the pair-fed group, which were comparable with vehicle controls
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