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186–188 It has also been reported that the effects of liraglutide on decreasing the hyperphosphorylation of tau by enhancing O-glycosylation of neuronal cytoskeleton protein, improving the JNK and ERK signaling pathway

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Thus, A2AR antagonists block the effects of adenosine and facilitate D2R agonist effects on lowering cAMP levels and then dampens PKA activity, which may result in neuroprotective effects