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How GIP and GLP-1 signaling combine The biology underneath tirzepatide is more subtle than “two appetite drugs stacked together.” GLP-1 receptor agonism acts on hypothalamic and hindbrain circuits that govern hunger and satiety, and peripherally it delays gastric emptying so that a meal produces prolonged fullness

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For now, and in the context of GLP therapy, it will be important to first better understand the insulin release and response kinetics in normal weight, nondiabetic patients before recommending these meds for a broader population.