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Trial data from STEP 4 (semaglutide) and SURMOUNT-4 (tirzepatide) show most of the weight is regained over 52–88 weeks after discontinuation
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For patients with existing heart disease, semaglutide's proven CV benefit is a major differentiator
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![Modulation of Endoplasmic Reticulum Stress via CEBPB: a Novel Therapeutic Target in Opioid Use Disorder[v1]](https://www.preprints.org/frontend/manuscript/342211c19537012ab8ed9c113b6632e4/download_pub/figure/graphic_abstract.png)
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