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glp 1 vs glp2 versus glp 2 Bispecific GLP-1/GLP-2 agonism in advanced type diabetes: preclinical characterization and a randomized, double-blind, Evolv Launches First Oral Fitness & Wellness Variety:Subscription
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When you're dehydrated: Plasma osmolality rises (more concentrated blood) The hypothalamus signals the choroid plexus to reduce CSF production to conserve water Total CSF volume drops from the normal 125-150 mL to as low as 100-110 mL The brain sits lower in the skull with less hydraulic support Position changes create larger pressure differentials A 2020 study in Fluids and Barriers of the CNS (Bothwell et al.) measured CSF production in mildly dehydrated subjects (2% body water loss, equivalent to missing 2-3 glasses of water per day) and found a 17% reduction in CSF turnover rate within 48 hours
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