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Of note, over the last years, an array of unimolecular GLP1-based poly-agonists, with different mechanisms of action, have been developed and experimentally validated for the treatment of metabolic syndrome, holding superior efficacy relative to conventional GLP1-RA 33,34,35
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Pre-filled pens for tirzepatide and semaglutide have spent long stretches on the UK shortage list since 2024, and patients are increasingly being prescribed compounded vials by private clinics — drawn with an ordinary insulin syringe, not a pen needle
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