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Furthermore, the application of a multifunctional agonist targeting the GLP-1, GIP, and delta-opioid (DOR) receptors—such as DPDPE—represents a novel therapeutic strategy for obesity, particularly given that DOR activation has been shown to independently improve glucose homeostasis (Olianas et al., 2011) and insulin sensitivity (Meulebrouck et al., 2024), as well as regulating emotional aspects of eating behavior (Wassum et al., 2009
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