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Many of the cardiovascular and metabolic trials informing the discussion were not designed to evaluate ophthalmic outcomes.¹ The authors called for prospective ophthalmology-specific studies incorporating imaging biomarkers, visual outcomes and disease-specific monitoring, noting that “parsing the protective benefits or adverse effects of this rapidly growing medication class will be essential to refining disease management and improve patient outcomes.”¹ As GLP-1 therapies become increasingly common among patients with diabetes, obesity and vascular comorbidities—precisely the populations populating ophthalmic clinics—the field may not have the luxury of waiting for cleaner data