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In silico docking studies indicate two probable binding sites for grassypeptolides: The active site of DPP-8 and one of the entrances to the internal cavity (Figure 7)

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4 Beyond diabetes: the non-glycaemic cardiovascular paradigm The expansion of incretin-based evidence from ASCVD in T2DM to obesity-associated cardiovascular disease, CKD, HFpEF, and PAD is summarized by clinical domain in Figure 1C