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63 Moreover, GLP-1RA treatment modulates the expression of additional barrier-associated genes, including IL-33, mucins, and CCL20—although the direction and magnitude of regulation vary depending on the colitis model, disease timepoint, and genetic background, complicating interpretation

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Researchers point to several overlapping mechanisms: Weight and fat reduction: Reducing visceral (abdominal) fat may ease the metabolic strain excess weight places on the cardiovascular system