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Activation of FXR inhibits the expression of sterol regulatory element-binding protein 1c (SREBP-1c) by enhancing small heterodimer partner (SHP) expression (32), and reduces the activity of lipogenic enzymes such as fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC), and stearoyl-CoA desaturase-1 (SCD-1), thereby lowering triglyceride levels (32, 33)