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In case patients have a dual therapy with either a SGLT-2 inhibitor or a TZD and are not at goal, a further treatment escalation to a triple therapy with a DPP-4 inhibitor can be implemented (70–72)

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Neither semaglutide nor tirzepatide currently appears on FDA's 503B bulks List or FDA's drug shortage list, largely foreclosing bulk compounding of “essentially a copy” of these agents by outsourcing facilities under Section 503B