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2 While impressive, this weight loss often includes muscle loss, which can compromise metabolic health if not managed with resistance training and proper protein intake

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Combination strategies, such as co-administration with standard-of-care oncologic treatments including chemotherapy, targeted therapies, and immune checkpoint inhibitors, should also be explored, as GLP-1 RAs may modulate treatment sensitivity through multiple biological axes, potentially offering synergistic effects, potentially enhancing efficacy while mitigating systemic toxicity through their known metabolic benefits [49]