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A 2025 real-world study of liraglutide, semaglutide, and dulaglutide reported substantial variability in both HbA1c and body-weight response after treatment initiation, supporting the concept that average treatment effects may obscure clinically meaningful subgroups (Heni et al., 2025)

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Tirzepatide for GERD is worth examining because this medication produces the most weight loss of any available anti-obesity drug, and weight loss is the single most effective lifestyle intervention for resolving gastroesophageal reflux disease