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Some studies have demonstrated the ability of gut-derived GLP-1 to cross through the blood-brain barrier and thoroughly perfuse the brain parenchyma, but whether its effects are similar to that of PPG-derived GLP-1 remains to be established [50, 53]
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Furthermore, GIPR and GLP1R are expressed within the heart and immune system, and GLP1R within the kidney, revealing putative mechanisms linking GIP and GLP1R agonism to cardiorenal protection
