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However, achieving that level of weight loss through lifestyle changes alone has generally not been feasible for most people

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Here’s a comparison to semaglutide showing that the novel compound leads to more weight loss (blue dots are semaglutide, red dots are the new compound, black dots are placebo, and the Y-axis is body weight): Hitting different receptors may also mean an impact on tolerability - one of the big issues with these medications in the real world