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These issues highlighted the vulnerabilities of a market that had rapidly expanded around temporary shortage exemptions rather than long-term regulatory frameworks
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Given the role of vascular dysfunction with both myocardial dysfunction and impaired exercise capacity in HFpEF 54 , and the known expression of GLP-1 receptors in the vasculature, we hypothesized that the weight loss-independent actions of semaglutide in HFpEF might involve improved vascular function
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