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Semaglutide hits one receptor. Tirzepatide hits two. Retatrutide hits three. The third receptor is the glucagon receptor — GCGR. And adding it changes the metabolic equation entirely. Glucagon is the counter-regulatory hormone

Patients with pre-existing vascular risk factors—including hypertension, dyslipidemia, and diabetic retinopathy—may be particularly susceptible

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The study selection process is illustrated in Figure 1