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This review was mainly summarized on the basis of research data, and therefore had limitations in many aspects: (1) Although we already knew that GLP-1RA inhibited the activation of microglia and promoted their polarization towards the M2 type, the regulatory mechanism of their induction of polarization in naive CD4 + T cells was still unknown, in particular their impact on the proportion of Tregs subtypes in T cells at the sites of infarct lesion