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Similarly, activation of TRPA1 in the gut (ion channel) slows gastric emptying, which then modifies the nutrient stimulus for GPCRs in the gut and pancreas (like GPR40 sensing fatty acids, or sweet taste receptors on K/L cells)

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Success won’t be measured only by who invents the most powerful molecule, but by who can build the ecosystem around it: scaling manufacturing without shortages, pricing with an eye toward sustainability, integrating digital engagement to improve adherence, and embedding these drugs into broader models of chronic care