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Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) Semaglutide and tirzepatide are examples of GLP-1 RAs, a category of peptides originally developed for diabetes management but found to promote weight loss through their actions on the pancreas and digestion

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For semaglutide alone, trials relating to cardiovascular disease (SELECT), kidney disease (FLOW) and heart failure (STEP) have announced positive results in the last 12 months