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The Key Difference: Receptor Activity The most significant distinction between Retatrutide and Semaglutide lies in the number of receptors they target

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Similarly, retatrutide does not yet feature in NICE guidelines, though its drug class (incretin-based therapies) is well-represented in guidance for type 2 diabetes (NICE NG28) and obesity management (NICE CG189), as well as in relevant Technology Appraisals covering licensed agents such as semaglutide