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In healthy subjects, oral glucose triggers a stronger insulin secretion response than intravenous glucose because of the secretion of incretin from the gastrointestinal tract, known as the “incretin effect.” Clinically, incretin-based drugs include glucagon-like peptide 1 receptor agonists (GLP-1 RA) (such as liraglutide) and dipeptidyl peptidase 4 inhibitors (DPP-4i) (such as vildagliptin)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 56.Heerspink HJ, Sattar N, Pavo I, Haupt A, Duffin KL, Yang Z, et al