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GLP-1 receptor agonists in atherosclerotic cardiovascular disease and diabetes mellitus or obesity: investigation of the potential role in a German inpatient dataset | Clinical Research in Cardiology | Springer Nature Link

Its long-acting effect is achieved through the following structural innovations: Amino acid modification: The alanine at position 8 is replaced with α-aminoisobutyric acid (Aib), which helps the molecule resist degradation by dipeptidyl peptidase-4 (DPP-4)

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None would exist without the VA research that demonstrated exendin-4's potential