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Semaglutide, by contrast, works exclusively through GLP-1 receptor activation, which means it engages one metabolic pathway rather than two

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Introduction/background: a novel dual incretin analog Despite historical research stating GIP did not assist in lowering blood glucose even with supratherapeutic levels, the success of GLP-1 RAs has led to the approval of a novel GLP-1/GIP RA, tirzepatide [42]