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102 Compared with the structure of human GLP-1(7-36), the amino acid sequence of albiglutide contains an arginine at position 8 (in GLP-1, this residue is lysine), and two modified GLP-1 peptide chains are fused to human serum albumin (HSA), thereby greatly extending its half-life
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This means it simultaneously activates the receptors for GIP, glucagon-like peptide-1 (GLP-1), and glucagon
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