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Tirzepatide is a once-weekly injectable medication approved by the FDA for chronic weight management in adults with obesity (BMI ≥30 kg/m²) or overweight (BMI ≥27 kg/m²) with at least one weight-related comorbidity

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Triple agonists like retatrutide 12 mg have demonstrated approximately 28.7% average weight loss over 68 weeks in Phase 3 trials