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Decreased appetite was also reported in ≥5% of patients taking semaglutide tablets The majority of reports of nausea, vomiting, and/or diarrhea occurred during dose escalation Ozempic ® injection: In placebo-controlled trials, discontinuation due to GI adverse reactions was 3.1% and 3.8% for the Ozempic ® injection 0.5 mg and 1 mg dose, respectively, compared with 0.4% for placebo Semaglutide tablets: 4% and 8% of patients discontinued semaglutide tablets 7 mg and 14 mg, respectively, due to GI adverse reactions, compared with 1% of patients receiving placebo Rates of hypoglycemia in placebo-controlled trials 1-3 Incidence of severe hypoglycemia was 300 mg/g at baseline) were randomized 1:1 to receive Ozempic ® injection 1 mg (n=1767) or placebo (n=1766) once-weekly, both in addition to standard-of-care treatments, including a maximum tolerated labeled dose of a renin-angiotensin-aldosterone system (RAAS) blocking agent, including an angiotensin converting enzyme (ACE) inhibitor or an angiotensin II receptor blocker (ARB), unless such treatment was contraindicated or not tolerated
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"Restarting helped, but it didn't fully restore the protection of uninterrupted use," the researcher emphasized
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