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Patients with a mean baseline HbA 1c of 8.1% (range 6.5%-10.7%) were randomized to receive either SYMLIN or placebo, both administered before major meals as add-on to insulin therapy
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However, pharmacological inhibition of active, sodium-coupled glucose transport impaired glucose-stimulated GLP-1 secretion in vitro , whereas inhibition of facilitative GLUT-mediated glucose transport was without effect [273]
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