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‍ TSH outside the 0.5–4.5 range warrants follow-up

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However, it is widely assumed that endogenous peripheral GLP-1 indirectly interacts with the central GLP-1 system (via vagal and/or endocrine routes) to control eating under physiological conditions, although this link is controversial and the necessary gut-brain circuitry has not been demonstrated empirically 4,15–17