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Considering that OSAS patients often present with multiple comorbidities—such as hypertension, coronary artery disease, and diabetes—further large-scale, long-term follow-up studies are needed to clarify tirzepatide’s safety in multimorbid populations (63, 64)

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Phase 3 results showed approximately 15-17% body weight reduction over 48 weeks, positioning it competitively with tirzepatide