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A small number of people also reported changes to their heart rhythm (arrhythmias) , though none of these were considered serious
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The apoptosis involved in SIMI encompasses the activation or inhibition of multiple pathways, including TNF-α and MAPK-related, PI3K/AKT/mTOR, and NF-κB signaling pathways, with the release of various inflammatory factors that directly lead to myocardial damage, resulting in increased secretion of inducible NO synthase and excessive production of NO (98,104)
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