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406 When GLP-1R is knocked out in astrocytes, it activates an integrated stress response, which affects the overall metabolic state by increasing the production of FGF21
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Eligible participants had CKD defined as either an eGFR of 50–75 mL/min/1.73 m 2 with UACR 300–5,000 mg/g, or an eGFR of 25 to 50% eGFR decline, ESKD, or all-cause mortality [81]
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