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Differences in trial design, participant populations, treatment duration, and endpoints mean that direct numerical comparisons between retatrutide Phase 2 data and semaglutide Phase 3 data are hypothesis-generating, not definitive

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It implies that not only the gut microbiota status could affect the GLP-1 secretion, but also GLP-1 could be considered as an effector in gut microbiota function by different mechanisms such as increasing the intestinal motility and decreasing the appetite