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Other transcriptional mechanisms regulating Gcg expression in α-cells include interaction of Cdx2/3, POU domain transcription factor brain 4 (Brn-4), hepatocyte nuclear factor 3 alpha (HNF3α

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Rybelsus is oral semaglutide, which requires a different formulation (the peptide is co-formulated with the absorption enhancer SNAC to survive gastric acid)