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In contrast, adults aged 45 to 54 make up just 16.1% of the obesity population, but comprise 24.3% of GLP-1 users

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The PKC-dependent effect of GLP-1 on membrane depolarization was mediated by activation of Trpm4 and Trpm5, and GLP-1 failed to increase electrical activity and insulin secretion in islets isolated from Trpm4 and Trpm5 KO mice [514]