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Metformin lowers blood glucose mainly by reducing hepatic glucose production (gluconeogenesis) and by improving insulin sensitivity in muscle cells, which allows muscles to take up more glucose from the bloodstream

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The consequences become evident in several ways: Reduced blood sugar control - As potency diminishes, patients may experience poor glucose management, potentially leading to hyperglycemia Decreased weight management results - The appetite-suppressing effects may weaken Unexpected side effects - Partially degraded medication can cause side effects not typically seen with properly stored semaglutide Bacterial contamination risk - Particularly for injectable formulations stored at improper temperatures Physical changes often signal degradation has occurred