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The biggest buzz around GLP-1 drugs these days has nothing to do with weight loss. And that might lead to some problems for patients and insurers., THE BIG PICTURE: Blockbuster treatments like Ozempic ...

Semaglutide functions as a GLP-1 receptor agonist, meaning it activates the same receptors as your body’s natural GLP-1

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Orforglipron addresses a single receptor pathway, while retatrutide addresses three: GIP, GLP-1, and the glucagon receptor