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In the phase 3 ACHIEVE-1 trial, published in June 2025, the oral small-molecule GLP-1 receptor agonist orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks in adults with

But while the public conversation focuses on hype and access, plan sponsors are left facing a different kind of challenge: soaring pharmacy costs, misinformation-driven demand, and a prescribing environment with little built-in cost control

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After years of steady weight gain and trying various remedies, she finally brought up the issue to her doctor again last spring