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For a more focused comparison of the first two compounds, see: Semaglutide vs Tirzepatide: What's the Difference
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Moreover, the modifications improve the specific high-affinity binding to albumin, which slows down the degradation of semaglutide in plasma and results in decreased renal clearance and in prolongation of the half-life of semaglutide to ~1 week, making it appropriate for once-weekly administration [51]
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