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The practical consequence is that GLP-1 RAs should be considered part of a layered cardiorenal strategy in high-risk T2DM with CKD, especially when atherosclerotic cardiovascular disease, obesity or persistent albuminuria are present (7, 35)
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45 Products that are a combination of a DPP-4 inhibitor and an SGLT2 inhibitor (sitagliptin/ertugliflozin, saxagliptin/dapagliflozin, and linagliptin/empagliflozin) may be used to further lower A1C and provide increased CV benefit in patients who are not meeting A1C goals on dual therapy
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