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At baseline, the mean eGFR was 37 mL/min/1.73 m2, 21% of patients had an eGFR equal to or above 45 mL/min/1.73 m2, 44% had an eGFR 30 to less than 45 mL/min/1.73 m2, and 35% had an eGFR less than 30 mL/min/1.73 m2

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Dose size alone cannot override underlying physiology or medical risk