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The STEP-HFpEF trial randomised 529 patients with obesity (BMI ≥30 kg/m 2 ), HFpEF (left ventricular ejection fraction [LVEF] ≥45%) and New York Heart Association (NYHA) Class ≥II symptoms to once-weekly subcutaneous semaglutide 2.4 mg or placebo.9 The semaglutide group exhibited significant improvements in symptoms and physical limitations, assessed using the Kansas City Cardiomyopathy Questionnaire Clinical Summary Score (KCCQ-CSS), with the change in KCCQ-CSS being the primary trial endpoint.9 Semaglutide also resulted in significant improvements in secondary endpoints, including the 6-minute walk distance and weight loss