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GLP-1 is a metabolic hormone that acts in the brain to shape reward, motivation, and cognition — weight loss follows as a secondary outcome of central regulation. Currently, GLP-1 is marketed for
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Scrocchi et al., 1996), this mechanism propelled the development of GLP-1 receptor agonists (GLP-1RAs), initially approved for diabetes (2005) and later for obesity (2014) (Jastreboff and Kushner, 2023)
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