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In diet-induced obese mice showing MASLD, the principal component analysis demonstrated that the combination of SGLT2i and GLP1-RA showed more potent beneficial effects on MASLD than SGLT2i and dipeptidyl peptidase-4 inhibitor 17
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The decision to combine these agents must be individualized based on patient-specific factors, including medical history, current medications, cardiovascular health, and response to previous weight management interventions
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