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What the Current Evidence Shows Retatrutide, covered in more detail in our retatrutide research overview and also known as LY3437943, is a single molecule designed to activate three receptor pathways involved in appetite, glucose regulation and energy balance: Glucose-dependent insulinotropic polypeptide receptors Glucagon-like peptide-1 receptors Glucagon receptors Its effects on these pathways can produce substantial changes in appetite and body weight

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1991), targeting the pathways involved in stimulus-secretion coupling in L-cells could provide an alternative strategy for the treatment of diabetes and obesity