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A 2025 real-world study of liraglutide, semaglutide, and dulaglutide reported substantial variability in both HbA1c and body-weight response after treatment initiation, supporting the concept that average treatment effects may obscure clinically meaningful subgroups (Heni et al., 2025)
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Tirzepatide for GERD is worth examining because this medication produces the most weight loss of any available anti-obesity drug, and weight loss is the single most effective lifestyle intervention for resolving gastroesophageal reflux disease
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![PDF] Effects Of GLP-1 Analogues, DPP-4 Inhibitors And SGLT2 Inhibitors On The Renal System](https://figures.semanticscholar.org/c15f0327b75d4570d8ee6263ce3f83d7e6f770a3/4-Table2-1.png)
